Topological superconductors have been theoretically predicted as a new class of time-reversal-invariant superconductors which are fully gapped in the bulk but have protected gapless surface Andreev bound states. In this work, we provide a simple criterion that directly identifies this topological phase in odd-parity superconductors. We next propose a two-orbital U-V pairing model for the newly discovered superconductor Cu_xBi₂Se₃. Due to its peculiar three-dimensional Dirac band structure, we find that an inter-orbital triplet pairing with odd-parity is favored in a significant part of the phase diagram, and therefore gives rise to a topological superconductor phase. Finally we propose sharp experimental tests of such a pairing symmetry.