We extend the use of holography to investigate the scrambling properties of various physical systems. Specifically, we consider: (i) non-conformal backgrounds of black Dp-branes, (ii) asymptotically Lifshitz black holes, and (iii) black AdS solutions of Gauss-Bonnet gravity. We use the disruption of the entanglement entropy as a probe of the chaotic features of such systems. Our analysis shows that these theories share the same type of behavior as conformal theories as they undergo chaos. However, in the case of Gauss-Bonnet gravity, we find a stark difference in the evolution of the mutual information for negative Gauss-Bonnet coupling. This may signal an inconsistency of the latter.