The eukaryotic nucleus is a dense heterogeneous environment, hosting a vast range of complex interactions. In the central spot light of this system, stands the DNA, or as it is called with its accompanying proteins, the Chromatin. Research in recent years has shown that spatial organization and hierarchical order of the chromatin folding is a basic and probably essential trait for accurate genetic activity. However, past studies have also shown that chromatin is dynamic - constantly undergoing structural modifications together with fundamental stochastic diffusion. These two traits – organization and random motion – seem to contradict on the most basic level.

In an attempt to solve this conundrum, we measure the diffusion of multiple chromatin loci via fluorescent microscopy, and study their relative motions. A data set of thousands of telomere and centromere pairs allows us to identify new long range mechanisms despite the inherent randomness in the system. We find significant distance dependent trends, and upon looking at cross correlations, also find domains of positive and negative step correlations. Our results show that chromatin interacts on length scales far beyond the chromosome territories.  Geometry driven analysis of the correlations leads us to propose a new model for chromatin large scale motion – an interconnected nucleus undergoing constant expansions and contractions. This model leads to unique modes of random motions that maintain the local and global organization of chromatin, thus helping to resolve the biological puzzle at hand.