Precise engineering of quantum states of matter and major advances in optical coherence and laser technology are elevating the performance of optical atomic clocks to new levels. A low-entropy Fermi gas of Sr atoms loaded into a three-dimensional optical lattice represents a powerful platform to discover, understand, and utilize many-body quantum systems that are metrologically powerful and lay the foundation for the connection between quantum simulation and quantum sensing. These increasingly powerful measurement capabilities are promising greater opportunities for probing fundamental and emerging phenomena.